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Cy3-UTP(10mM) 抑胃肽酶液 PERFEMIKER AuroraGel 标准型基质胶，不含LDEV
光引发剂LAP 人工胃液 1%柠檬酸钠缓冲液 Salkowskis比色液 人工脑脊液(aCSF,无菌)
S-(5'-腺苷)-L-高半胱氨酸简介：
SAH是氨基酸衍生物和几种代谢途径中的调节剂。 它是半胱氨酸和腺苷合成的中间体。
1.S-(5'-腺苷)-L-高半胱氨酸产品物理参数：
2.S-(5'-腺苷)-L-高半胱氨酸同类产品列表：
3.S-(5'-腺苷)-L-高半胱氨酸生物活性：
天然产物 >> 酸和醛
研究领域 >> 其他
4.S-(5'-腺苷)-L-高半胱氨酸物理化学性质：
5.S-(5'-腺苷)-L-高半胱氨酸安全信息：
6.S-(5'-腺苷)-L-高半胱氨酸海关：
7.S-(5'-腺苷)-L-高半胱氨酸文献：
EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.
Tijana Miti?, Andrea Caporali, Ilaria Floris, Marco Meloni, Micol Marchetti, Raul Urrutia, Gianni D Angelini, Costanza Emanueli
文献索引：Mol. Ther. 23(1) , 32-42, (2015)
全文：HTML全文
摘要
Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses gene transcription. We explored (i) if EZH2 expression is regulated by hypoxia and ischemia; (ii) the impact of EZH2 on the expression of two pro-angiogenic genes: eNOS and BDNF; (iii) the functional effect of EZH2 inhibition on cultured endothelial cells (ECs); (iv) the therapeutic potential of EZH2 inhibition in a mouse model of limb ischemia (LI). EZH2 expression was increased in cultured ECs exposed to hypoxia (control: normoxia) and in ECs extracted from mouse ischemic limb muscles (control: absence of ischemia). EZH2 increased the H3K27me3 abundance onto regulatory regions of eNOS and BDNF promoters. In vitro RNA silencing or pharmacological inhibition by 3-deazaneplanocin (DZNep) of EZH2 increased eNOS and BDNF mRNA and protein levels and enhanced functional capacities (migration, angiogenesis) of ECs under either normoxia or hypoxia. In mice with experimentally induced LI, DZNep increased angiogenesis in ischaemic muscles, the circulating levels of pro-angiogenic hematopoietic cells and blood flow recovery. Targeting EZH2 for inhibition may open new therapeutic avenues for patients with limb ischemia.
8.S-(5'-腺苷)-L-高半胱氨酸英文别名:
S-(5'-Adenosyl)-L-homocysteine、(2S)-adenosylhomocysteine、Adenosylhomocysteine、Adenosyl-L-homocysteine、AdenosylhoMocysteine-13C5、(2S)-2-Amino-4-({[(2S,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl}sulfanyl)butanoic acid (non-preferred name)、HOMOCYSTEINE,S-ADENOSYL、L-S-AdenosylhoMocysteine、s-adenosylhomocysteine、S-ADENOSYL-L-HOMOCYSTEINE、L-adenosyl-L-homocysteine、hpce、ADOHCY、5'-DEOXY-S-ADENOSYL
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